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Though I had a negative experience on my last go of it, and a “root”-based filesystem still confuses me, this was one of the big solid advantages last time I checked a few distros. I followed some advice of putting the system-level directories on one partition, and my user content on a different one. When I got fed up with one distribution, I cleaned and reinstalled things onto the system-level partition, leaving the user directory alone; I just had to inform it where those directory mappings would go.
Very doubtful that it would work, but out of all the weird, crazy, and creative stories generated from World War 2, I wouldn’t put it totally outside of any plausibility.